to cause someone to no longer have a friendly relationship with another person or other people

Her lifestyle estranged her from her parents. 她的生活方式使她跟父母越来越疏远。

to cause you to feel that you do not understand someone or something, or do not have any connection with him, her, or it

Cultural changes can estrange the reader from old texts. 文化演变可能导致读者难以理解旧时作品的内容。