If someone or something is weighed down with something, they are carrying a lot of or too much of it.

Weighed down with supplies, they found the steep path difficult to climb. 由于背着沉重的补给品，他们觉得陡峭的小路很难攀爬。

to make a person feel worried and unhappy because of problems, responsibilities, and duties

I thought she looked somehow older, weighed down by all her new responsibilities. 我觉得她被那些新职责弄得心力交瘁，看上去都老了些。

Too much responsibility when too young can weigh down on a child. 年幼时背负过多的责任会使孩子不堪重负。