not conscious of where you are or what condition you are in as a result of taking alcohol or drugs

She was lying on the sofa, totally out of it. 她躺在沙发上，完全失去了知觉。

unhappy because you are not included in what is happening

I didn't know anyone at the party, and I felt really out of it. 聚会上我一个人也不认识，感觉很不是滋味。