to control something or someone to your advantage, often unfairly or dishonestly

Throughout her career she has very successfully manipulated the media. 她在整个职业生涯中非常成功地控制了媒体。

The opposition leader accused government ministers of manipulating the statistics to suit themselves. 反对派领导人指责政府部长篡改统计数据以满足自身利益。

to control something using the hands

The wheelchair is designed so that it is easy to manipulate. 轮椅设计得很容易用手控制。

to treat a part of the body, using the hands to push back bones into the correct position and put pressure on muscles

The doctor manipulated the base of my spine and the pain disappeared completely. 医生对我的脊柱底部进行了推拿，疼痛便完全消失了。