A loaded gun has bullets in it.

It's dangerous to leave a loaded gun lying around. 把上了膛的枪随便乱放很危险。

not fair, especially by being helpful to one person instead of another

It seems that the report is loaded in favour of the developers. 这篇报道似乎有些偏袒开发商。

a question that has particular words chosen to suggest the answer that is wanted

A survey should avoid asking loaded questions. 调查应该避免问一些诱导性的问题。

rich

He inherited the family business - he must be loaded! 他继承了家族企业——一定很有钱！

drunk

What a party - everyone was loaded! 聚会很尽兴——大家都喝醉了！