the feeling of being angry or annoyed, or something that makes you feel like this

That kind of behaviour is sure to cause irritation. 那种行为肯定会让人感到恼火。

Traffic noise is just one of several minor irritations (= small problems). 交通噪声只是烦人的琐事之一。

a painful or sore feeling in a part of the body

It is an antiseptic cream suitable for minor skin irritations. 这种杀菌乳膏适用于轻微皮炎。

The strap had rubbed against his skin and caused irritation. 皮带擦伤了他的皮肤引起了发炎。