to die

If a machine gives up the ghost, it stops working.

Our old TV had finally given up the ghost. 我们的老电视终于坏了。

to stop trying to do something because you know that you will not succeed

All I'd cherished from early childhood had been denied me, so I simply gave up the ghost. 我自童年起珍惜的一切都被夺走了，我只好放弃。