毁掉；伤害；使苦恼；搞砸a rude phrase meaning to damage, harm, or upset someone or something, or to do something very badly
Her parents' divorce really fucked her up. 她父母的离婚使她很苦恼。
I fucked up the interview. 我把面试搞砸了。
The exam was a disaster - I really fucked up. 那次考试真是场灾难——我考得一塌糊涂。