to leave or go away, used especially as a rude way of telling someone to go away

Just fuck off and leave me alone! 滚开，让我一个人呆一会儿！

He's fucked off somewhere and left me to do all the work. 他滚到别的地方去了，留下我一个人干所有的活儿。

a rude phrase meaning to annoy or upset someone very much

You speak to me as if I'm stupid and it really fucks me off. 你那样跟我说话，就好像我是个蠢货，真把我气坏了。