very large in amount or degree

extreme pain/stupidity/wealth 极其痛苦／愚蠢／富有

very severe or bad

extreme weather conditions 极其恶劣的天气条件

In extreme cases, the disease can lead to blindness. 极端情况下，这种疾病可导致失明。

Extreme beliefs and political parties are considered by most people to be unreasonable and unacceptable.

He has rather extreme views. 他的观点很偏激。

He's on the extreme right wing of the party. 他属于这个政党的极右翼势力。

at the furthest point, especially from the centre

They live in the extreme south of the island. 他们住在这个岛的最南端。

the largest possible amount or degree of something

I've never witnessed such extremes of wealth and poverty. 我从未见过如此悬殊的贫富差别。

Most people I know work fairly hard but she takes it to extremes. 我认识的人里大多数工作都很努力，但是她这种干法也太不要命了。

used for emphasis; extremely

Some of the scenes were unpleasant in the extreme. 有些场景令人极其反感。

Her criticisms of his work were petty in the extreme.

Their treatment of captured soldiers was harsh in the extreme.

It is ironic in the extreme that this wealthy man is calling for pay cuts.

I'm afraid her reading of the situation is naive in the extreme.

a situation, feeling, etc. that is the opposite or very different from another one

My moods seem to go from one extreme to another (= my moods often change from very bad to very good). 我的情绪时而极好，时而又糟糕得要命。