to make someone extremely tired

The long journey exhausted the children. 长途旅行后，孩子们疲惫不堪。

I've exhausted myself with all that cleaning. 打扫卫生累得我精疲力尽。

to use something completely

How long will it be before the world's fuel supplies are exhausted? 再过多长时间地球上的燃料就耗尽了？

I'm afraid he's exhausted my patience. 恐怕我对他已经失去耐心了。

We seem to have exhausted this topic of conversation (= we have nothing new to say about it). 这个话题我们好像已经没有什么好谈的了。

the waste gas from an engine, especially a car's, or the pipe the gas flows through

Car exhaust is the main reason for the city's pollution. 汽车尾气是造成城市污染的主要原因。