without taking any notice of or being influenced by; not prevented by

I still enjoyed the week despite the weather. 尽管天气不好，这一周我过得还是很愉快的。

Despite repeated assurances that the product is safe, many people have stopped buying it. 尽管已反复保证了该产品的安全性，很多人还是不再购买。

[ + -ing verb ] He managed to eat a big lunch despite having eaten an enormous breakfast. 尽管早餐吃了很多，他午饭还是大吃了一顿。

If you do something despite yourself, you do it although you do not want to or although you know you should not.

He laughed despite himself. 他忍不住笑了起来。

She took the money from her mother's purse, despite herself. 她忍不住从母亲的钱包里拿了钱。

He was attracted to Rachel despite himself.

She smiled despite herself.

He became a great success, almost despite himself.

Despite myself, I warmed to him.