to cause someone to feel unhappy and without hope

This weather depresses me. 这种天气让我感到心情忧郁。

[ + -ing verb ] Doesn't it depress you listening to the news these days? 这些天的新闻不让你感到沮丧吗？

[ + to infinitive ] It depresses me to think that I'll probably still be doing exactly the same job in ten years' time. 想到10年后很可能还在干同样的工作，我就感到非常沮丧。

to reduce the value of something, especially money

A surplus of corn has helped depress the grain market/grain prices. 玉米过剩促使粮食价格降低。

The rise in the value of the dollar has depressed the company's earnings/profits this year. 今年美元升值导致该公司营业额／利润降低。

to reduce the amount of activity in something, especially a business operation

High interest rates are continuing to depress the economy. 高利率使经济持续萧条。

to lower the level or amount of something

This drug helps depress high hormone levels. 这种药物有助于降低荷尔蒙水平。

to press down or lower

Slowly depress the accelerator/brake pedal. 慢慢踩下油门／制动踏板。