If an event or series of events culminates in something, it ends with it, having developed until it reaches this point.

My arguments with the boss got worse and worse, and finally culminated in my resignation. 我和老板的争吵日益恶化，直到最终我决定换工作。

Their many years of research have finally culminated in a cure for the disease. 经过多年研究，他们终于开发出一种能治愈该病的药物。