the final line in the accounts of a company or organization, stating the total profit or loss that has been made

How will the rise in interest rates affect our bottom line? 利率上升对我们的盈亏状况会有什么影响？

the most important fact in a situation

The bottom line is that we need another ten thousand dollars to complete the project. 基本问题是我们还需要一万美元来完成这个项目。