to cause someone such difficulties that they do not know how to deal with you

He's the despair of his parents because he shows no interest in getting a job. 他对找工作没有任何兴趣，让父母感到非常头疼。

At school, I was extremely badly behaved and the despair of my poor teachers.

She failed all her exams and was the despair of her mother.

The whole band were the despair of their manager.

That whole family must be the despair of the authorities.

See also: despair noun