the feeling that you have no connection with the people around you or that you are not part of a group

Depressed people frequently feel a sense of alienation from those around them. 情绪抑郁的人经常有与周围人格格不入的感觉。

the act of making someone stop supporting and agreeing with you

This short-sighted alienation of their own supporters may lose them the election. 这种疏远自己支持者的短视做法或许会使他们输掉选举。