sometimes happy and sometimes sad

She's been very up and down since her husband went into hospital. 自从丈夫住院以后，她的情绪波动很大。

everywhere in a particular area, especially an area that stretches from north to south

Cities up and down the East Coast are preparing for the storm. 东海岸各地城镇都在为迎接风暴做准备。

Cinemas up and down the country are reporting huge audiences for the film. 据报道，该影片在全国各地电影院的上座率都很高。