to become familiar with somewhere new, such as a new house, job, or school, and to feel comfortable and happy there

Once we've settled in, we'll have you over for dinner. 一旦我们安顿下来，一定要请你过来吃饭。

to help someone to become familiar with a new job or a new place where they will be living, working, or staying

The nurse will be with you soon - she's settling a new patient in at the moment. 护士马上就会到你这里来——她现在正在安顿一位新来的病人。