to not leave your home and to stay away from other people when you have, or may have, an infectious disease, so that you do not infect anyone else

If you have been told to self-isolate, you need to stay indoors and avoid contact with other people for 14 days. 如果你被告知要自我隔离，你需要呆在室内并避免与其他人接触14天。

The British government is advising thousands of people to self-isolate to prevent the spread of COVID-19.

She stayed home from work to self-isolate herself from co-workers, and began to feel better by late last week.